I did once a simple model in AutoCAD 3D. While modelling was easy, other features like smoothing of edges did not work. The round shape stayed polygonal. I guess it had something to do with how the model is converted into .3ds (or any other rexport format, that can be converted to Orbiter msh).
If you are a seasoned 3D cad designer, learning any 3D modelling programm should be fairly easy. I went for Gmax, a popular Autodesk product then.
A 3D program usually gives better control on edges and faces, which allows to build the models lightweight (not too many polygons).
Whatever way you choose:
- Check how the model can be converted into msh.
- Look how the model can be textured and how the textures look in Orbiter.