I still haven't done it. My friend finally beat it on Easy after many weeks. His own ship was destroyed simultaneously but it counted.
We both had the Advanced Content or whatever enabled. I don't think it changes the difficulty but it does enhance the game elements.
I think you're going to want to unlock a few spaceships before winning becomes conceivable.
On easy I won my second time. I find it difficult to lose on easy. The odds have to be stacked against you badly. The only times I lose on Easy now is if I go through all the sectors and not find (buy, find, force others to give up) enough weapons to get through the enemy shields and do damage...
The first ship you get is actually pretty decent. It doesn't excel in any area, but it doesn't lag behind either. It's easy to upgrade and offers a variety of play styles.
Every other ship asks you to sacrifice something in order to gain something - the ship that is "best" asks you to sacrifice whatever isn't in your play style and gives you whatever is in your play style.
Here are some tips I found useful:
- Don't rush through the sectors. You always want to make sure that you just barely escape the pursuing fleet. That will allow you to accumulate more scrap.
- When enemy surrenders, they usually offer less scrap, but more fuel, missiles and drones. If you destroy them, you get more scrap. Only accept surrender if they're offering exactly what you need and you're in desperate need of them. Usually it's better to destroy the ship, get the scrap and buy the materials.
- Shields are better then engines. Shields will guarantee protection from one hit (except missiles and bombs), where engines will only offer you a chance. Upgrade shields FULLY before upgrading engines. I usually don't leave sector one without upgrading shields to 2 and usually don't leave sector 3 before upgrading them to 3.
- Don't use autofire. What you want to do is wait for all of your lasers to fully charge, then fire them in one massive burst. That won't give the enemy enough time to recharge the shields so part of your fire won't go into nothing.
- Always fire on weapons first. There are very very few exceptions to that and usually only when the enemy can't hurt you much. A very sophisticated drone system can sometimes be worse than enemy weapons, that's usually the most common exception.
- Don't rely on missiles and bombs. They get through the shield, yes, but there is limited ammo. Only use them in cases of emergency - where you don't stand a theoretical chance of destroying the enemy ship (it has 3 shields, you have only the ability to fire 3 lasers to down the shields, but not actually do damage) or when you're taking damage. Save the ammo for the end boss. You'll need it...
- Fight fires by evacuating compartments of air, but NEVER evacuate your door or your O2 room. If you evacuate your O2 room and the O2 is destroyed, you're almost guaranteed to lose crewmen attempting to fix O2. If you evacuate the door control room and the doors and airlocks are stuck open, you'll lose people.
- When fixing stuff in evacuated areas of the ship, send one crew in first, then the next one a few seconds later. Keep exchanging your entire crew between the sick bay and whatever you're repairing. That way nobody will die and the repair will take place at all times. If at any point no crew is repairing the system, you'll lose the progress they've made.
- Upgrade your sensors and doors by 1. If you have spare scrap, also your O2 by one (but don't power it). Upgrading sensors by one will allow you to see the interior of the enemy ship - where the crew is. You can see what areas of the ship the crew is repairing, so you can target that system - that has two effects. The first is that the system doesn't get repaired and the crew is stuck repairing that system from scratch. The second is that you can hurt or kill crew members, further slowing the repairs. Sensors take no extra power. If you upgrade doors, they also take no extra power. This helps you in three ways: If there's a fire, it spreads far more slowly from room to room, so it gives you more time to evacuate the compartment without the fire spreading. If you have intruders, they'll take more time to blast through the doors, giving you more time to suffocate them. And the third is that the system now takes twice as much damage before going down. This is very useful when fighting fires and intruders...